Developmental Behavioral Pediatrics Research Network
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Maternal Immune Status and Autism Severity

Maternal Immune Status and Autism Severity

Participating Sites: UC David MIND, The Children’s Hositpal of Philadelphia, University of Arkansas

Objectives

 This study proposes to replicate the presence of maternal autoantibodies in mothers of children with Autism Spectrum Disorders (ASD) in a geographically diverse population (Pennsylvania and Arkansas) utilizing the Developmental-Behavioral Pediatrics Research Network (DBPNet) and determine the association of these antibodies with autism severity and behavioral impairments.

 

Aim 1: To examine the maternal antibody pattern to autism-specific fetal brain proteins in relation to autism severity and developmental profile/behavioral outcome.

            Hypothesis 1: Children of mothers with autoantibodies reactive to either the 37/73 kDa or the 39/73 kDa target antigens will have more severe autism symptoms and developmental/behavioral impairments, including lower expressive language and increased stereotypic behavior, than children with ASD whose mothers do not have these antibodies. 

            Hypothesis 2 (Exploratory): Children of mothers with 39/73 kDa reactivity will have milder autism and developmental/behavioral deficits than children with maternal 37/73 kDa reactivity.